Decreased blood-brain barrier P-glycoprotein function with aging
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منابع مشابه
Decreased blood-brain barrier P-glycoprotein function with aging
A48 Decreased blood-brain barrier P-glycoprotein function with aging Martin Bauer, Rudolf Karch, Aiman Abrahim, Claudia C Wagner, Kurt Kletter, Markus Müller and Oliver Langer Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria Department of Medical Computer Sciences, Medical University of Vienna, 1090 Vienna, Austria Department of Radiopharmaceuticals, Austr...
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AIM To examine whether the transport of nimodipine (NMD) from the circulating blood into the brain is restricted by P-glycoprotein (P-gp) in rat brain capillary endothelial cells (BCEC). METHODS When cells reached confluence, a time course of NMD uptake was recorded by incubation with a medium containing NMD 10 mg/L at 37 degrees C. Effects of various agents in the steady-state uptake of NMD ...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2008
ISSN: 1471-2210
DOI: 10.1186/1471-2210-8-s1-a48